NCT04186026

Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.

Effect of Combination of the Gut Hormones Neurotensin and GLP-1 on Physiological Regulation of Appetite and Food Intake

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.

Detailed description

Neurotensin (NT), a gut hormone and neuropeptide, and GLP-1, as well a gut hormone, increases in circulation after bariatric surgery in rodents and humans and inhibit food intake in mice. Studies in rodents have shown that a GLP-1 receptor agonist and long acting neurotensin inhibit food intake. This study investigates whether the synergistic anorexic effects of neurotensin and GLP-1 agonism suggested by animal studies can be translated.

Conditions

• Obesity

Interventions

Type	Name	Description
OTHER	Saline + saline	Double saline infusion followed by an ad libitum meal
OTHER	Neurotensin + saline	Neurotensin + saline infusion followed by an ad libitum meal
OTHER	GLP-1 + saline	GLP-1 + saline infusion followed by an ad libitum meal
OTHER	GLP-1 + Neurotensin	GLP-1 + Neurotensin infusion followed by an ad libitum meal

Timeline

• Start date: 2019-10-01
• Primary completion: 2024-06-10
• Completion: 2024-06-30
• First posted: 2019-12-04
• Last updated: 2023-05-17

Locations

2 sites across 1 country: Denmark