NCT04185935

Molecular Genetics Studies of Cancer Patients and Their Relatives

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 999,999 (estimated)
• Sponsor: City of Hope Medical Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.

Detailed description

PRIMARY OBJECTIVES: I. To identify rare cancer patients and families in whom the pattern of disease suggests a genetic susceptibility to cancer or other etiology suggestive of a carcinogenic exposure and to characterize the underlying predisposition. II. To determine the contribution of heredity (genotype) and biomarkers to clinical outcome (phenotype, occurrence of new cancers, prognosis and quality of life) in subgroups of cancer patients with and without clinical high-risk features. OUTLINE: Patients may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue.

Conditions

• Malignant Neoplasm

Interventions

Type	Name	Description
OTHER	Biospecimen Collection	Provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue
OTHER	Questionnaire Administration	Ancillary studies

Timeline

• Start date: 1997-04-18
• Primary completion: 2033-08-18
• Completion: 2033-08-18
• First posted: 2019-12-04
• Last updated: 2025-06-25

Locations

42 sites across 5 countries: United States, Colombia, Mexico, Peru, Puerto Rico