NCT04184141

Preoperative Use of Alprazolam and Hydroxyzine in Anxiety

The Effect of Hydroxyzine and Alprazolam Premedication on Preoperative Anxiety and Patient Satisfaction

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Istanbul Medeniyet University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Patients will be divided into three groups. Group H patients will be given 100 mg Hydroxyzine orally 1 hour before surgery while group A patients will receive 0.5 mg Alprazolam orally. group P will be placebo group. Amsterdam Preoperative Anxiety and Knowledge Scale (APAIS) anxiety scores will be evaluated and recorded 1 hour before surgery. APAIS score will be evaluated again in the the operation room before surgery started. After base measurements of patients are recorded with standard monitoring, spinal block will be performed with 15 mg Heavy Bupivacaine from the L2-L3 or L3-L4 levels of spinal cord in sting position. When T10 level sensory block and Bromage 0-1 neuromusculer block will be occured , surgery will be started. Heart rate, non-invasive arterial blood pressure and the degree of peripheral O2 saturation will be measured at 5 minutes interval throughout the operation. IOWA anesthesia satisfaction scale will also performed to the patients the day after the surgery.

Conditions

• Agitation on Recovery From Sedation

Interventions

Type	Name	Description
DRUG	Hydroxyzine Hydrochloride	Hyroxyzine hydrochloride is given to the patient one hour before surgery.
DRUG	Alprazolam tablet	Alprozolam is given to the patient one hour before surgery.
DRUG	Placebo	Placebo candy

Timeline

• Start date: 2019-12-01
• Primary completion: 2020-06-01
• Completion: 2020-09-01
• First posted: 2019-12-03
• Last updated: 2019-12-06