NCT04181957

Effects of LDX on Cognitive Processes and Appetite

The Effects of Lisdexamfetamine Dimesylate on Cognitive, Metabolic, and Reward Processes in Individuals With Binge-eating Symptoms

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: University of Birmingham · Academic / Other
• Sex: Female
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will investigate the effect of lisdexamfetamine dimesylate (LDX) on the mediating factors of reward and cognition on appetite.

Detailed description

This study will investigate the specific reward and cognitive mechanisms that mediate the effects of LDX on eating in participants with sub-clinical binge-eating disorder symptoms. A sub-clinical sample will be recruited in line with the Research Domain Criteria Initiative established by the US National Institute of Mental Health which encourages research on dimensions of observable behaviour rather than a categorical, symptom-based approach to the study of mental health. The tendency towards binge-like eating will be modelled using an eating in the absence of hunger paradigm in which participants consume a pasta meal and are then offered the opportunity to consume as many palatable cookies as they like. Reward processes will be assessed by measuring neural and behavioural responses to palatable food pictures using functional Magnetic Resonance Imaging (fMRI). Responses to emotional stimuli will be assessed using the P1vital® Oxford Emotional Test Battery. Impulsive responding will be assessed using the delay discounting task and the stop signal task. Attentional processing will be assessed using the sustained performance task and working memory will be assessed with the n-back task.

Conditions

• Binge Eating
• Eating Behavior

Interventions

Type	Name	Description
DRUG	Placebo oral tablet	Participants take one dose of placebo (lactose) tablet.
DRUG	Lisdexamfetamine Dimesylate	Participants take one 50mg tablet of lisdexamfetamine dimesylate once.

Timeline

• Start date: 2019-05-01
• Primary completion: 2020-03-17
• Completion: 2020-03-17
• First posted: 2019-12-02
• Last updated: 2020-11-06

Locations

1 site across 1 country: United Kingdom