NCT04179188

Impact of Bariatric Surgery in Obese Patients With and Without Obstructive Sleep Apnea Syndrome

Impact of Bariatric Surgery in Obese Patients With and Without Obstructive Sleep Apnea Syndrome - COLOSS

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Ramsay Générale de Santé · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It has been shown to date that obesity is associated with increased mortality and that weight loss significantly improves cardiovascular risk factors. Among patients receiving bariatric surgery, 30-90% have moderate to severe obstructive sleep apnea (OSA) syndrome. Given the strong associations between OSA and cardiometabolic comorbidities, this project is based on the hypothesis of a lower improvement of cardiovascular risk factors and a higher number of post-surgical complications in OSAS patients.

Detailed description

It has been shown to date that obesity is associated with increased mortality and that weight loss significantly improves cardiovascular risk factors. Bariatric surgery is now the most effective intervention for the long-term treatment of obesity and its complications. Among patients receiving bariatric surgery, 30-90% have moderate to severe obstructive sleep apnea (OSA) syndrome. The progressive loss of weight contributes to the regression of the symptoms related to OSA. Observational studies have shown that bariatric surgery can rapidly improve glycemic control and cardiovascular risk factors with a significantly higher remission rate of hypertension and dyslipidemias than in the non-surgical group. Given the strong associations between OSA and cardiometabolic comorbidities, this project is based on the hypothesis of a lower improvement of cardiovascular risk factors and a higher number of post-surgical complications in OSAS patients.

Conditions

• Obesity
• Bariatric Surgery Candidate
• Apnea, Obstructive

Interventions

Type	Name	Description
PROCEDURE	Bariatric surgery	Classical Bariatric surgery (ring, Sleeve gastrectomy or Bypass)

Timeline

• Start date: 2019-10-09
• Primary completion: 2025-11-30
• Completion: 2026-05-31
• First posted: 2019-11-27
• Last updated: 2019-11-27

Locations

1 site across 1 country: France