NCT04178512

Intrathecal Additives to Prevent Post Spinal Shivering in Transurethral Prostatectomy

Effect of Intrathecal Dexamethasone Versus Fentanyl on Post Spinal Shivering in Patients Undergoing Transurethral Prostatectomy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (estimated)
• Sponsor: Zagazig University · Other Government
• Sex: Male
• Age: 50 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Spinal anesthesia is the technique of choice in transurethral prostatectomy.However,one of the common complications of spinal anesthesia is shivering which is even exaggerated in patients undergoing transurethral prostatectomy.this high incidence is most probably caused by sympathetic block and use of large amount of irrigation fluid during surgery.There are two methods to reduce shivering.Previous studies showed that intrathecal fentanyl is an appropriate method to reduce shivering.Intrathecal dexamethasone could reduce shivering by regulating immune responses.

Detailed description

Shivering is an involuntary repetitive contractions of skeletal muscles that increases the basal metabolism and is considered to be a defense mechanism for regulating body temperature in adults . Post spinal shivering may cause discomfort to the patient,and may aggravate wound pain by stretching incisions and increases intracranial and intra ocular pressure.Shivering may increase tissue oxygen demand as much as 500% and is accompanied by increase in minute ventilation and cardiac output to maintain aerobic metabolism. Tympanic temperature will be recorded preoperatively,after establishment of spinal anesthesia,and every 15 minutes til the end of operation.Core temperature below 36.5 C is considered as hypothermia Shivering intensity will be assessed with a five -point scale validated by Crossly and Maharaj. Adverse events like hypotension,bradycardia, respiratory depression,nausea and vomiting will be recorded and treated.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Drug:dexamethasone in group Dexamethasone,fentanyl in group Fentanyl,normal saline 0.9%in group Control	prevention of shivering after spinal anesthesia in patients undergoing trans urethral prostatectomy through injection of spinal additives

Timeline

• Start date: 2019-12-01
• Primary completion: 2020-05-01
• Completion: 2020-06-01
• First posted: 2019-11-26
• Last updated: 2019-12-03