NCT04178304

Effect of Prolotherapy in Knee Osteoarthritis.

Effect of Prolotherapy in Knee Osteoarthritis: Clinical and Ultrasonographic Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: University of Alexandria · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Patients with primary knee osteoarthritis will be included in the study, plain X-ray for the affected knee, followed by musculoskeletal ultrasound assessment will be done. The intervention: intra-articular injection and extra-articular injections of 25% dextrose. Follow up will be done at 24 weeks after the last injection both clinically and ultrasonographically . Aim: Determine whether prolotherapy improves pain. stiffness and function of symptomatic knee osteoarthritis and determine ultrasonographic changes before and after prolotherapy.

Detailed description

Sixty knees with primary knee osteoarthritis will be included in the study, clinical assessment will be done, then plain X-ray for the affected knee (s), followed by musculoskeletal ultrasound assessment will be done. The intervention: 1. a single intra-articular injection of 6 mL of 25% dextrose through infero-medial or infero-lateral approach will be done. 2. extra-articular injections will be done at major tender tendons and ligaments through 15 skin punctures using peppering technique and placing a possible total of 22.5 mL of 25% dextrose. * Both intra and extra-articular injections will be done at 1, 5, 9, and 13 weeks intervals. Follow up will be done at 24 weeks after the last injection both clinically and ultrasonographically .

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
DRUG	Prolotherapy with 25% Dextrose	Intra-articular injection of 6mL of 25% dextrose Extra-articular injection at tender sites with 25% dextrose

Timeline

• Start date: 2019-12-15
• Primary completion: 2021-10-30
• Completion: 2021-12-30
• First posted: 2019-11-26
• Last updated: 2023-04-05

Locations

1 site across 1 country: Egypt