NCT04178135

Recombinant LH Supplementation Timing Strategies (From Day 1 or Day 6) to a Standard GnRH Agonist Long Protocol in Subsequent COS Cycle of Older Patients With Unexpected Poor or Suboptimal Ovarian Response

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya · Academic / Other
• Sex: Female
• Age: 35 Months – 40 Years
• Healthy volunteers: Accepted

Summary

A randomized, controlled, pilot study, for Patients ≥ 35 years and \< 40 years old with sufficient ovarian reserve parameters (AFC≥ 5), but showed an unexpected poor or suboptimal ovarian response(defined as ≤ 9 retrieved oocytes in previous full-stimulation cycle, but not get live birth after all embryos were used ). In order to get better oocyte number and quality in the new COS cycle, we will compare LH supplementation from beginning with from middle of stimulation in GnRH-a long protocol.

Conditions

• Infertility,Female

Interventions

Type	Name	Description
DRUG	rLH	rLH supplement from day 1 of stimulation
DRUG	rLH	rLH supplement from day 6 of stimulation

Timeline

• Start date: 2019-12-25
• Primary completion: 2022-12-30
• Completion: 2022-12-30
• First posted: 2019-11-26
• Last updated: 2022-01-11

Locations

2 sites across 1 country: China