Trials / Completed
CompletedNCT04177641
Evaluation of Thioldisulfide Balance in Cervical Preinvasive Lesions
Investigation of Thiol-disulfide Balance in Cervical Preinvasive Lesions
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 300 (actual)
- Sponsor
- Muğla Sıtkı Koçman University · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to investigate Thiol-disulfide balance in patients with cervical preinvasive lesions
Detailed description
To date various oxidative stress paramaters were studied in patients with cervical preinvasive lesions, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel \& Neselioglu(1). References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/ disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/ j.clinbiochem.2014.09.026.
Conditions
- Oxidative Stress
- Low Grade Squamous Intraepithelial Lesion
- High-Grade Squamous Intraepithelial Lesions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Disulphide(μmol/L) | Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry |
| DIAGNOSTIC_TEST | Total Oxidant Capacity(μmolH2O2Equiv/L) | Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry |
Timeline
- Start date
- 2018-09-20
- Primary completion
- 2020-01-01
- Completion
- 2020-01-10
- First posted
- 2019-11-26
- Last updated
- 2020-02-06
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT04177641. Inclusion in this directory is not an endorsement.