NCT04176835

Oxytocin and Social Decision Making in Schizophrenia

Neurobiological Effects of Oxytocin on Social Decision Making in Schizophrenia: A Pharmacological MRI Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: National Institute of Mental Health and Neuro Sciences, India · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

schizophrenia patients and healthy volunteers will be included. Subjects who meet the inclusion and exclusion criteria for the study will be recruited. After completion of clinical assessments and neuropsychological assessments, all subjects will undergo two fMRI scans. In one scan subjects will receive a single dose of intranasal oxytocin and in another scan, they will receive intranasal saline. The order of administration of oxytocin or saline will be counterbalanced so that they are not administered in the same order to all subjects. Subjects will be blind to the drug administered.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DRUG	Oxytocin nasal spray	Single-dose oxytocin will be administered intranasally
DRUG	Placebo

Timeline

• Start date: 2016-04-01
• Primary completion: 2019-09-01
• Completion: 2019-09-01
• First posted: 2019-11-25
• Last updated: 2022-09-29