NCT04175067

Evaluation of Thiol Disulfide Balance in Stage 1 Endometrium Cancer

Assessment of Thiol Disulfide Balance in Early Stage Endometrium Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 117 (actual)
• Sponsor: Muğla Sıtkı Koçman University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate thiol-disulfide balance in early stage endometrium cancer patients.

Detailed description

To date various oxidative stress paramaters were studied in patients with endometrial cancer, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel \& Neselioglu(1). References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.

Conditions

• Endometrium Cancer
• Oxidative Stress

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Disulphide(μmol/L)	Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry
DIAGNOSTIC_TEST	Total Oxidant Capacity(μmolH2O2Equiv/L)	Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry

Timeline

• Start date: 2018-08-01
• Primary completion: 2019-10-31
• Completion: 2019-11-15
• First posted: 2019-11-22
• Last updated: 2019-11-22

Locations

1 site across 1 country: Turkey (Türkiye)