NCT04171882

Microglial Cells Activation Imaging Using PET-CT With 18F-DPA714

In Vivo Assessment of Neuroinflammation With 18-FDPA714 PET/CT

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Weibing Miao, PhD · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in brain injury and degeneration. It is considered that microglial activation would be part of self-propelling cycle of neuroinflammation that fuels Neurologic deterioration. It is however hard to evidence microglial activation in vivo: first, the investigators need very high-resolution imaging tools and then, the only ligand available to date, 11C-PK11195, has a low sensitivity and specificity and provided heterogeneous results. 18F-DPA-714 is a new PET ligand which labels microglial cells. The investigators aim to explore the clinical feasibility used PET-CT with 18F-DPA714 to monitor microglial cells activation of brain in several different disease. This study might reveal significant neuroinflammatory process in the brain. The results of this study might provide a new biomarker of disease pathological progression and help as identifying subjects who might most benefit from a specific anti-inflammatory drug.

Conditions

• Microglial Cells Activation Imaging

Timeline

• Start date: 2019-11-01
• Primary completion: 2024-11-01
• Completion: 2024-11-01
• First posted: 2019-11-21
• Last updated: 2021-11-23

Locations

2 sites across 1 country: China