NCT04168853

Impact of Pumps on Internal Thoracic Arteries (IPITA)

Cardiopulmonary Bypass and Internal Thoracic Arteries: Can Roller or Centrifugal Pumps Change Vascular Reactivity of the Grafts

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory response. The purpose of this study was to compare the vascular reactivity and the inflammatory response of the internal thoracic arteries (ITAs) between patients undergoing coronary artery bypass grafting (CABG) under CPB with a roller pump or with a centrifugal pump.

Detailed description

Eighty elective male patients undergoing CABG were selected using one or two internal thoracic arteries under CPB with a roller pump (RP group) or centrifugal pump (CFP group). ITA samples were collected before starting CPB (Time 1) and before the last coronary anastomosis during aortic cross clamping (Time 2). Terminal complement complex activation (SC5b-9) and neutrophil activation (elastase) analysis were performed on arterial blood at the same times.

Conditions

• Coronary Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	vascular reactivity of internal thoracic arteries	1. Internal thoracic arteries analysis Myography Superoxide detection and confocal microscopy Immunochemistry Quantitative real time transcription-polymerase chain reaction (RT-PCR) analysis 2. Blood sampling and biochemical analysis

Timeline

• Start date: 2015-11-03
• Primary completion: 2017-11-08
• Completion: 2017-12-08
• First posted: 2019-11-19
• Last updated: 2019-11-21