NCT04167982

Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Acne Vulgaris

Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for the Treatment of Moderate and Severe Acne Vulgaris-- A Multi-center, Randomized Controlled Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 234 (estimated)
• Sponsor: Shanghai Dermatology Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study is being done to compare a new, continuous illumination and short Incubation time regimen of 5-aminolevulinic acid photodynamic therapy (painless ALA- PDT) to low-dose and conventional dose of oral isotretinoin for treatment of moderate or severe acne vulgaris. The hypothesis is that the painless ALA- PDT will be equally or more efficacious as oral isotretinoin, and taking effect more quickly with less adverse effect.

Conditions

• Acne

Interventions

Type	Name	Description
PROCEDURE	Aminolevulinic acid photodynamic therapy	Aminolevulinic acid photodynamic therapy
DRUG	Oral conventional-dose isotretinoin	Conventional-dose isotretinoin
DRUG	Oral low-dose isotretinoin	low-dose isotretinoin

Timeline

• Start date: 2020-03-28
• Primary completion: 2022-11-30
• Completion: 2022-11-30
• First posted: 2019-11-19
• Last updated: 2020-11-24

Locations

1 site across 1 country: China