NCT04167722

How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages (Exosomes) From Fat Tissue in Lean and Obese Patients

The EXOPRO Study: How Does Prostate Cancer Metastasize? Understanding the Role of Exosomal Communication in Lean vs Obese Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: Male
• Age: —
• Healthy volunteers: Not accepted

Summary

The investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.

Detailed description

Both obesity and prostate cancer are major health problems in the UK, affecting 1 in 3 and 1 in 8 men respectively. Moreover, obesity increases the risk of developing aggressive disease and the risk of prostate cancer spreading. How this happens is not known. The investigators want to understand how fat cells communicate with prostate cancer cells. Investigators will be collecting prostate and fat tissue from radical prostatectomy participants for culture, in particular to look at exosome communication.

Conditions

• Prostate Cancer
• Obesity

Interventions

Type	Name	Description
PROCEDURE	Robotic Radical Prostatectomy	Routine NHS Radical Prostatectomy

Timeline

• Start date: 2019-10-01
• Primary completion: 2023-10-01
• Completion: 2024-10-01
• First posted: 2019-11-19
• Last updated: 2021-09-22

Locations

1 site across 1 country: United Kingdom