NCT04167098

Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger

A Prospective Randomized Placebo-controlled Trial Comparing Platelet-rich Plasma and Corticosteroid Injection for Treatment of Trigger Finger

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 117 (estimated)
• Sponsor: Töölö Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Study purpose is to evaluate the effectiveness of Platelet-rich Plasma (PRP) injection in the treatment of trigger finger. We compare PRP to a corticosteroid (methylprednisolone) injection in a prospective randomized triple-blind placebo-controlled study. Patients with clinically confirmed trigger finger are randomized (1:1:1 computer generated sequence with random block size) to three parallel groups and will receive an injection of either PRP, corticosteroid or placebo (0.9% saline) around the affected tendon sheath in a double-blind setting. Baseline data is collected and is followed by a phone call at 1 month, and follow-up visits at 3, 6, 12 and 24 months after the intervention. Unveiling of the allocation is at 6 months post-intervention. The primary outcome measures are: * Symptom resolution * Patient-Rated Wrist Evaluation Secondary outcomes: * Quick-Disabilities of the Arm, Shoulder and Hand * Pain Visual Analogue Score * Global improvement (7-step Likert-scale) * Grip strength * Finger range of motion

Conditions

• Tendon Entrapment

Interventions

Type	Name	Description
OTHER	PRP injection	0.5 ml Platelet-rich Plasma around A1 tendon sheath
OTHER	Corticosteroid injection	0.5 ml methylprednisolone around A1 tendon sheath
OTHER	Placebo injection	0.5 ml 0.9% saline around A1 tendon sheath

Timeline

• Start date: 2019-11-01
• Primary completion: 2021-07-01
• Completion: 2022-07-01
• First posted: 2019-11-18
• Last updated: 2020-12-17

Locations

1 site across 1 country: Finland