NCT04161794

Multimodal Intervention for Patients With Non-small Cell Lung Cancer

Multimodal Intervention (Dietary Counselling, Fish Oil and Physical Training) for Patients With Non-small Cell Lung Cancer, a Feasibility Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Aalborg University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A single-arm intervention study assessing the feasibility of a multimodal intervention of management of cancer cachexia in patients with non-small cell lung cancer during primary anti-neoplastic treatment. The effects of the intervention is compared to a historical control group

Detailed description

In a single arm intervention study, we will provide a multimodal intervention consisting of dietary counselling, physical exercises plan as well as fish oil. The target of the dietary counselling is: * 30 kcal/kg/d (in patients with BMI \<30) or 25 kcal/kg/d (in patients with BMI =\> 30) * at least 1.0 g protein/kg/d * three daily meals of at least 20 g of protein * restrict overnight fasting to a maximum of 11 hours The initial dietary counselling is at the first cycle of anti-neoplastic treatment. The patient will be provided an individual plan to meet the dietary targets tailored to the individual preferences and symptoms. At every cycle of anti-neoplastic treatment, the plan will be adjusted if needed. At every week the patients will be prompted by telephone to comply with the dietary plan. The physical exercise consists of two exercises: * strength training: a progressive sit-to-stand exercise which is a lower extremity exercise. * cardio-vascular training: a progressive brisk walking plan. Patients are prompted to execute both exercises twice weekly. The individual targets are set at the first cycle of anti-neoplastic treatment and adjusted during the trial. Fish oil: The patients are instructed to ingest 10g of liquid fish oil (consisting of 2 g EPA/DHA) or 8 capsules of fish oil (consisting of 2 g EPA/DHA)

Conditions

• Cachexia; Cancer

Interventions

Type	Name	Description
OTHER	multimodal	2 g EPA/DHA as fish oil, repeated dietary counselling and twice weekly 2 x exercises

Timeline

• Start date: 2018-02-15
• Primary completion: 2019-04-30
• Completion: 2019-04-30
• First posted: 2019-11-13
• Last updated: 2019-11-13

Locations

1 site across 1 country: Denmark