NCT04159181

The Endocrine Colon in Humans

Investigations of the Endocrine Colon in Healthy Individuals

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will examine the role of the colon as an endocrine organ with a focus on the secretion of gastrointestinal peptides.

Detailed description

This study will examine the role of the colon as an endocrine organ with a focus on the secretion of gastrointestinal peptides. We aim to determine the contribution of the colon to the fasting and postprandial release of gut peptides such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Young healthy men will be examined on three occasions at a clinical research Facility after an overnight fast. On one occasion the colon will also be emptied using a cathartic (picoprep). On two occasions an oral solution of lactulose will be administered to stimulate fermentation by colonic bacteria.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Lactulose	Oral solution lactulose (20g lactulose/200mL water).
OTHER	Picoprep	Cathartic to accomplish an evacuation of the colonic content.
OTHER	Placebo (water)	oral administration of Water (200mL).

Timeline

• Start date: 2018-07-16
• Primary completion: 2019-07-31
• Completion: 2020-07-01
• First posted: 2019-11-12
• Last updated: 2019-11-12

Locations

2 sites across 1 country: Denmark