NCT04154150

Ketamine + Cognitive Training for Suicidality in the Medical Setting: Pilot

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Rebecca Price · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to identify the acute and longer-term impact of a single dose of intravenous ketamine among suicidal patients referred for psychiatric consultation/liaison in the medical inpatient setting. The investigators will then test whether ketamine's rapid effects can be extended by introducing helpful information delivered by a computer-based training protocol. This work could ultimately lead to the ability to treat suicidality more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

Detailed description

NOTE: In the course of this pilot study, both the primary and secondary outcome measures were supplemented to provide additional, complementary information on the clinical effects of the study interventions, based on confirmation (through study team experience) of the feasibility of acquiring such additional information in the context of our study population, setting, and design.

Conditions

• Suicide, Attempted

Interventions

Type	Name	Description
DRUG	Intravenous ketamine	Single subanesthetic infusion of ketamine (0.5mg/kg)
BEHAVIORAL	Cognitive training	8 sessions of computer-based cognitive training
BEHAVIORAL	Sham Training	8 sessions of computer-based sham training

Timeline

• Start date: 2019-12-19
• Primary completion: 2022-03-15
• Completion: 2022-03-15
• First posted: 2019-11-06
• Last updated: 2024-07-22
• Results posted: 2023-01-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study