NCT04146532

Aspirin Effects on Emotional Reactions

Effects of Aspirin on Emotional Reactivity, Memory, and Risk-taking

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 268 (actual)
• Sponsor: Ohio State University · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to determine whether the drug aspirin has effects on emotional reactivity, emotional memory, and risk-taking behaviors.

Detailed description

The goal of this study is to determine if aspirin (acetylsalicylic acid) alters emotional reactions to emotion evoking pictures as well as memory for them. Using a double-blind parallel arm study, participants will receive either placebo or a pain-relieving dose of aspirin (500mg). One hour later they will complete 30 minutes of tasks. This will include ratings of emotional pictures and memory for them. The paradigm is similar to previous experiments done in this lab using other cyclooxygenase inhibitors: ibuprofen and acetaminophen (Durso, Luttrell, \& Way, 2015; Psychological Science, https://doi.org/10.1177/0956797615570366). Risk taking on the Balloon Analogue Risk Task will also be assessed. Participants will be healthy young adult males at Ohio State University.

Conditions

• Healthy Adults

Interventions

Type	Name	Description
DRUG	Aspirin 500 MG	Single 500mg aspirin capsule.
DRUG	Placebo	Single 500mg placebo capsule.

Timeline

• Start date: 2019-10-08
• Primary completion: 2022-04-15
• Completion: 2022-04-15
• First posted: 2019-10-31
• Last updated: 2024-06-03

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study