Trials / Terminated
TerminatedNCT04146389
Hyperprolactinemia and Adrenal Steroidogenesis
Hyperprolactinemia and Adrenal Steroidogenesis: is There a Link?
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 5 (actual)
- Sponsor
- Insel Gruppe AG, University Hospital Bern · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to explore the effects of prolactin on adrenal steroid profiles in patients with hyperprolactinemia due to prolactinomas before and after initialisation of treatment.
Detailed description
Prolactin is known to influence many biological processes. One potential target is the adrenal gland, where prolactin may stimulate the production of adrenal steroid hormones. Conditions of increased prolactin production(hyperprolactinemia) could, therefore, increase concentrations of adrenal steroids. One of the potential implications would be false doping accusations of athletes engaging in elite sports. This interaction between prolactin and adrenal steroidogenesis, however, remains poorly understood, and the available research findings are conflicting. The investigators, therefore, seek to explore the relationship between prolactin and adrenal steroidogenesis by monitoring prolactin levels and blood and urinary steroid profiles of patients with hyperprolactinemia due to prolactinomas before and after treatment initialisation.
Conditions
Timeline
- Start date
- 2021-06-24
- Primary completion
- 2023-11-06
- Completion
- 2023-11-06
- First posted
- 2019-10-31
- Last updated
- 2023-12-06
Locations
1 site across 1 country: Switzerland
Source: ClinicalTrials.gov record NCT04146389. Inclusion in this directory is not an endorsement.