NCT04146259

Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 109 (actual)
• Sponsor: University of Athens · Academic / Other
• Sex: Female
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

Detailed description

Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy. Based on the development of biochemical hypocalcemia (cCa \< 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism. Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Conditions

• Hypoparathyroidism Postprocedural

Interventions

Type	Name	Description
DRUG	calcium carbonate and alphacalcidol	treatment for hypocalcemia

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-12-31
• Completion: 2019-08-01
• First posted: 2019-10-31
• Last updated: 2019-11-01

Locations

1 site across 1 country: Greece