NCT04144621

Sperm DNA Fragmentation Effects on Blastocyst Morphology Grading, Pregnancy Rate and Implantation Rate

The Correlation of Sperm DNA Fragmentation With Blastocyst Grading and Its Implantation Potential

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 189 (actual)
• Sponsor: Ganin Fertility Center · Academic / Other
• Sex: All
• Age: 37 Years
• Healthy volunteers: —

Summary

Retrospective cohort study for 189 couples assigned to normal and abnormal Sperm DNA fragmentation (SDF) groups.To determine the effect of SDF on blastocyst's trophectoderm (TE), Inner cell mass (ICM) morphology grading, and implantation rate. Semen in both groups was processed by density gradient (DG).

Detailed description

Purpose: to determine if sperm DNA fragmentation (SDF) has a correlation with Blastocyst's trophectoderm (TE) and Inner cell mass (ICM) grading, or with the implantation rate? Method: Retrospective cohort study for 189 couples, assigned to normal SDF group (121 cases), and abnormal SDF group (68 cases). Semen in both groups was processed by double layer density gradient (DG). Statistical analysis done using SPSS version 22.

Conditions

• Blastocyst
• Implantation Rate

Interventions

Type	Name	Description
PROCEDURE	ICSI	Intracytoplasmic sperm injection of female partner oocytes with ejaculated sperm selected by density gradient centrifugation

Timeline

• Start date: 2018-01-01
• Primary completion: 2019-04-01
• Completion: 2019-04-01
• First posted: 2019-10-30
• Last updated: 2019-11-01

Locations

1 site across 1 country: Egypt