NCT04143568

Circulating Progenitor Cells Levels in Periodontal Disease Patients

Analysis of Circulating Progenitor Cells Levels in Periodontal Disease Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 167 (actual)
• Sponsor: University of Messina · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Recently, a key role played in the ethiology of periodontitis has been highlighted by a subtype of stem cells derived from bone marrow, the circulating endothelial progenitor cells (EPCs). EPCs possess the ability to express surface antigens of endothelial and hematopoietic stem cells and to assist in maintaining vascular integrity and the repair mechanism of the endothelium. Among the main markers for the analysis of EPCs levels are CD34+, CD133+ and the kinase insert domain-containing receptor (KDR). CD34+ and CD133+ originate from hematopoietic stem cell antigens whereas KDR is a specific marker of endothelial cells. More specifically, CD34+ and CD133+/ KDR+ allows less mature and mature EPCs to be evaluated.

Detailed description

The aim of the present study was to investigate the association between endothelial progenitor cells (EPCs) levels subtype (CD133+/KDR+), in patients with periodontitis. Furthermore, the objective was to determine if the periodontal status influenced CD133+/KDR+ levels.

Conditions

• Metabolic Disease

Interventions

Type	Name	Description
OTHER	Observation	Evaluation of endothelial progenitor cells level and correlation of endothelial progenitor cells level with periodontal and cardiovascular disease

Timeline

• Start date: 2016-02-01
• Primary completion: 2018-10-30
• Completion: 2018-11-30
• First posted: 2019-10-29
• Last updated: 2019-10-29

Locations

1 site across 1 country: Italy