NCT04143386

Prognostic Hemodynamic and Metabolic Profiles of Late Stage Lower Extremity Arterial Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 750 (estimated)
• Sponsor: University of Tartu · Academic / Other
• Sex: All
• Age: 35 Years – 85 Years
• Healthy volunteers: —

Summary

Late stage lower extremity arterial disease (LEAD) is known to be associated with hemodynamic and metabolic abnormalities and very poor long-term prognosis. The prognostic value of hemodynamic and metabolic profiling, however, is yet to be determined in this patient group. Current study aims to identify novel prognostic biomarkers for better risk stratification of late stage LEAD patients. It also allows to determine associations between hemodynamic/arterial stiffness indices, low-molecular weight metabolites and other substances (e.g. mediators of inflammation and bone-mineral metabolism, cardiac and kidney injury biomarkers, microRNAs) thus providing potentially valuable insight into the pathogenic mechanisms of this disease.

Conditions

• Lower Extremity Arterial Disease (Fontaine Stages IIb-IV)

Timeline

• Start date: 2019-11-04
• Primary completion: 2024-12-31
• Completion: 2025-12-31
• First posted: 2019-10-29
• Last updated: 2019-10-29

Locations

1 site across 1 country: Estonia