NCT04141592

Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease

Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease: Cross-sectional Comparative Study Between Patients and Healthy Controls

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 153 (estimated)
• Sponsor: Queen Mary University of London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To identify key characteristics of the tissue resident and peripherally circulating immune-phenotype in addition to blood markers, metabolic profile, faecal and oral microbiota in non-alcoholic fatty liver disease

Detailed description

In this study, the investigators will collect tissue, blood, stool, urine and saliva samples at the same time in order to enable a comprehensive disease phenotyping and ability to compare immunological, microbiological and metabolic features in patients with varying stages of NAFLD and healthy controls. To date there are limited published data evaluating simultaneously-obtained samples from adipose, gut and liver tissue and peripheral blood in NAFLD. The majority of participants in this study will be recruited from the bariatric surgery services enabling multiple tissue samples to be collected at time of surgery with minimal additional risk to participants.

Conditions

• Non-Alcoholic Fatty Liver Disease

Interventions

Type	Name	Description
PROCEDURE	Bariatric Surgery	Already clinically indicated surgical procedures

Timeline

• Start date: 2019-03-05
• Primary completion: 2026-04-01
• Completion: 2026-04-01
• First posted: 2019-10-28
• Last updated: 2025-06-03

Locations

1 site across 1 country: United Kingdom