NCT04141306

Radioiodine-avid Bone Metastases From Thyroid Cancer Without Structural Abnormality

Radioiodine-avid Bone Metastases From Differentiated Thyroid Cancer Without Structural Abnormality, a Singular Entity With Heterogeneous Outcomes.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Bone radioiodine (RAI) uptake without structural abnormality in thyroid cancer (TC) patients may be related to false positive or to microscopic foci of metastatic tissue. In such cases, outcome is reported to be excellent. Indeed, Robenshtok et al. reported a serie of patients with RAI-avid bone metastases of TC without structural abnormality on imaging studies who have more favorable long-term prognosis than those harbouring structurally visible bone metastases and do not undergo skeletal-related complications. The investigators report the case of Mrs D., who had been operated for a pathologic tumor stage 3: pT3(m) poorly differentiated TC at the age of 43. The first post-therapeutic whole body scan revealed 3 foci of bone uptake (right clavicle, L2, L3). The elevated level of thyroglobulin (157ng/mL) favoured the hypothesis of bone metastases despite the absence of any structural lesion on CT and MRI. She received 7 courses of radioiodine therapy. The right clavicle RAI uptake persisted, and subsequent CT disclosed an osteolytic lesion which was treated by radiofrequency and external beam radiation. Twenty-five years after the diagnosis, she has a persistent morphological disease with a 30x8mm progressive lesion on the right clavicle, for which surgery is planned. The aim of the present study is to describe the natural history and evolution of radioiodine avid bone metastases from thyroid cancer without structural abnormalities and to identify prognosis factors.

Conditions

• Bone Metastases
• Thyroid Cancer

Interventions

Type	Name	Description
OTHER	Administrative data	Evaluation of month and year of birth, sex, referent doctor and surgeon
OTHER	Clinical data	Evaluation of diagnostic circumstances, vital status at last follow up
OTHER	Histological data	Evaluation of Pathology report of thyroid surgery
OTHER	Imaging data	Evaluation of scintigraphy, MRI, scan
OTHER	Biological data	Evaluation of thyroglobulin, antithyroglobulin antibodies
OTHER	Further treatment	Evaluation of surgery, radiotherapy, targeted therapy

Timeline

• Start date: 2019-11-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2019-10-28
• Last updated: 2019-10-28