Trials / Completed
CompletedNCT04140045
The Effect of Manipulating Hydration Status During Cycling in the Heat on Acute Kidney Injury Biomarkers
The Effect of Hypohydration During Cycling in the Heat on Acute Kidney Injury Biomarkers
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 14 (actual)
- Sponsor
- Loughborough University · Academic / Other
- Sex
- Male
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
Acute Kidney Injury (AKI) is common in prolonged endurance events. Risk factors for exercise-associated AKI include: the exercise itself, heat, hypohydration, muscle breakdown and non-steroidal anti-inflammatory drug (NSAID) use. Prior research from our laboratory showed the hypohydration during high-intensity running increased a biomarker of AKI (urine osmolality-corrected kidney injury molecule 1). Therefore, the current study will now investigate the effect of manipulating hydration status during cycling on biomarkers of AKI.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Water intake | Water intake will be manipulated in both arms to create a hypohydrated state and a euhydrated state, post-exercise |
Timeline
- Start date
- 2019-10-28
- Primary completion
- 2020-03-17
- Completion
- 2020-03-17
- First posted
- 2019-10-25
- Last updated
- 2020-08-03
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT04140045. Inclusion in this directory is not an endorsement.