NCT04138537

Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Bezmialem Vakif University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. Olfactory bulb(OB) volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.

Detailed description

Acromegaly patients were assessed at the Endocrinology Department for their clinical symptoms, and the nasal examination and olfactory evaluation were done at the Department of Otorhinolaryngology. OB volume was evaluated by a single blinded radiologist. Control group patients that had similar demographical characteristics with the Acromegaly Group were recruited in the study. The CCCRC test is composed of n-butanol odor threshold test and odor identification test. Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. OB measurements were done individually on the right and left olfactory bulbs and the mean OB volume was calculated in cubic millimeters.

Conditions

• Acromegaly
• Olfactory Disorder

Interventions

Type	Name	Description
OTHER	OB volume	The mean OB volume was calculated in cubic millimeters and compared between the two groups.
OTHER	CCCRC test	CCCRC test was done for olfactory function assessment and compared between the two groups.

Timeline

• Start date: 2018-08-15
• Primary completion: 2019-12-10
• Completion: 2020-01-30
• First posted: 2019-10-24
• Last updated: 2020-03-16

Locations

1 site across 1 country: Turkey (Türkiye)