NCT04138472

Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Sana Urooj · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy

Detailed description

Direct laryngoscopy and intubation are painful stimulus that activates sympathoadrenal discharge which results in intense cardiovascular reflex i.e. tachycardia and hypertension. In this study we will compare effects of intravenous dexmedetomidine, fentanyl and lidocaine for attenuation of these reflexes in patient undergoing laproscopic cholecystectomy. how these agents will effect hemodynamic response during pneumoperitoneum. Tertiary objective will be to observe sedation, perioperative complications and recovery in these patients.

Conditions

• Laparoscopic Cholecystectomy

Interventions

Type	Name	Description
DRUG	dexmedetomidine	intravenous dexmedetomidine 0.06mg/kg in 100ml normal saline 0.9% over 10minutes.
DRUG	fentanyl	intravenous fentanyl at 2mcg/kg in 100ml saline over 10 minutes in induction room.
DRUG	lidocaine	intravenous lidocaine 1.5mg/kg in 100ml saline over 10 minutes in induction room.

Timeline

• Start date: 2019-10-30
• Primary completion: 2020-02-29
• Completion: 2020-02-29
• First posted: 2019-10-24
• Last updated: 2020-02-07

Locations

2 sites across 1 country: Pakistan