NCT04134078

Improving Outcomes in Cardiac Arrest With Inhaled Nitric Oxide

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Stony Brook University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sudden cardiac arrest (CA) is a leading cause of death worldwide. CA claims the lives of an estimated 300,000 Americans each year. Despite advances in cardiopulmonary resuscitation (CPR) methods, only approximately 10% of adults with CA survive to hospital discharge, and up to 60% of survivors have moderate to severe cognitive deficits 3 months after resuscitation. Most of the immediate and post-CA mortality and morbidity are caused by global ischemic brain injury. The goal of this grant application is to test the hypothesis that resuscitation from cardiac arrest can be improved by improving cerebral oxygenation through inhalation of nitric oxide. This strategy will also improve the chances of return of spontaneous circulation (ROSC), improve short-term survival and neurologic outcome.

Conditions

• Cardiac Arrest

Interventions

Type	Name	Description
DRUG	inhaled nitric oxide	Inhaled nitric oxide at 40 ppm will be administered upto 24 hours post ROSC in patient who developed in hospital cardiac arrest

Timeline

• Start date: 2016-08-01
• Primary completion: 2020-07-01
• Completion: 2022-07-01
• First posted: 2019-10-21
• Last updated: 2019-10-21

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study