NCT04133805

The Effect of Viscous Dietary Fibers on LDL-cholesterol

The Effect of Viscous Dietary Fibers on LDL-cholesterol: A Systematic Review and Meta-analysis of Randomized Controlled Trials

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 7,845 (actual)
• Sponsor: Unity Health Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This systematic review and meta-analysis is aimed to assess the effect of commonly consumed viscous fibers on blood lipids including LDL-C, non-HDL-C, and ApoB.

Detailed description

Medline, Embase, CINAHL, and the Cochrane Central databases were searched through May 13, 2019. Three independent reviews extracted data and assessed risk of bias. Randomized controlled trials that assessed the effect of barley b-glucan, oat b-glucan, konjac glucomannan (KJM), psyllium, guar gum, and pectin, with a study duration of ≥ 3 weeks, in adults with or without hypercholesterolemia were included. Data were pooled using the generic inverse variance method with random effects models and expressed as mean differences with 95% confidence intervals. Heterogeneity was assessed by the Cochran Q statistic and quantified by I2 statistic. Overall quality of the evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.

Conditions

• Cardiovascular Risk Factor
• Hypercholesterolemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	viscous fiber	ex. barley b-glucan, oat b-glucan, konjac glucomannan, psyllium, guar gum, and pectin

Timeline

• Start date: 2018-09-17
• Primary completion: 2019-12-01
• Completion: 2020-01-01
• First posted: 2019-10-21
• Last updated: 2019-10-21

Locations

1 site across 1 country: Canada