NCT04130633

Behavioral Pharmacology of THC and Alpha-pinene

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate the pharmacokinetics and pharmacodynamics of vaporized alpha-pinene and THC administered via inhalation.

Detailed description

The proposed study will be conducted at the Johns Hopkins Behavioral Pharmacology Research Unit (BPRU). Participants will complete 6 acute drug administration periods in which they will administer THC alone, pinene alone, THC and pinene together, or placebo. Subjective drug effects, cognitive performance, and vital signs will be assessed following drug administration. Each participant will receive all 6 dose conditions in a randomized order using a placebo controlled within-subject crossover design. The study will help the investigators understand the individual and interactive effects of THC and pinene, two common constituents found in cannabis.

Conditions

• THC
• Alpha-pinene

Interventions

Type	Name	Description
DRUG	Placebo	Placebo vapor (distilled water)
DRUG	THC	Pure THC vapor
DRUG	Alpha-Pinene	Pure alpha-pinene vapor

Timeline

• Start date: 2020-11-05
• Primary completion: 2024-03-08
• Completion: 2024-03-08
• First posted: 2019-10-17
• Last updated: 2025-05-22
• Results posted: 2025-05-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study