NCT04126096

Negative Predictive Value and NIC of Beta-Lactam Antibiotics.

The Negative Predictive Value and Non-irritant Skin Testing Concentrations of Beta-Lactam Containing Antibiotics Other Than Penicillin.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 747 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The researchers are trying to evaluate how much medication is required for allergy skin testing and to determine the likelihood that patients with a negative test truly don't have an allergy to the tested drug of skin testing to commonly used antibiotics.

Detailed description

This study will be a prospective study to accurately determine the negative predictive value of skin testing with beta lactam containing antibiotics other than penicillin . It is hypothesized that the concentrations that should be used for beta lactams are actually much lower than previously recommended and that the higher incidence of identifiable beta lactam induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).

Conditions

• Allergy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Skin Testing beta-lactams	Percutaneous skin prick followed by Intradermal Injections of NMBAs at increasing concentrations compared with an established positive and negative control.

Timeline

• Start date: 2019-09-20
• Primary completion: 2023-01-06
• Completion: 2023-01-06
• First posted: 2019-10-15
• Last updated: 2023-06-22

Locations

2 sites across 1 country: United States