NCT04122456

DNA Repair Activity in the Skin of Day and Night Shift Workers

Pilot Study on DNA Repair Activity in the Skin of Day and Night Shift Workers

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: Wright State University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.

Conditions

• Skin Cancer

Interventions

Type	Name	Description
RADIATION	Ultraviolet B Radiation	One skin punch biopsy will be taken to the laboratory for exposure to ultraviolet B radiation. After 1-hour incubation, the biopsies will be bisected in half.
OTHER	No Ultraviolet B Radiation	One skin punch biopsy will be taken to the laboratory and will be kept as a non-irradiated control.

Timeline

• Start date: 2022-12-07
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2019-10-10
• Last updated: 2025-02-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study