NCT04122287

Helicobacter Pylori First-line Treatment in Patients Allergic to Penicillin

Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin:a Prospective Randomized Controlled Study

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in patients allergic to penicillin.

Detailed description

Helicobacter pylori(H.pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. Strongly evidence supports that H.pylori eradication is an effective approach to reduce the incidence of those pathologies.However,Helicobacter pylori eradication is a challenge in patients allergic to penicillin. Therefore, the investigators aim to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in patients allergic to penicillin.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Levofloxacin	levofloxacinn-tetracycline-containing quadruple regimens
DRUG	tinidazole	tinidazole-tetracycline-containing quadruple regimens

Timeline

• Start date: 2019-11-01
• Primary completion: 2022-10-01
• Completion: 2022-12-01
• First posted: 2019-10-10
• Last updated: 2021-11-18

Locations

1 site across 1 country: China