NCT04121416

Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Shengjing Hospital · Academic / Other
• Sex: Female
• Age: 60 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

Detailed description

Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR \[1.2\]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Conditions

• Cardiovascular

Interventions

Type	Name	Description
DRUG	Oxycodone 10mg	induction with 0.3mg/kg of oxycodone in general anesthesia
DRUG	Sufentanil	induction with 0.3 µg/kg of Sufentanil in general anesthesia

Timeline

• Start date: 2019-04-01
• Primary completion: 2019-08-31
• Completion: 2019-09-19
• First posted: 2019-10-09
• Last updated: 2019-10-09

Locations

1 site across 1 country: China