NCT04120870

Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients

Comparison of Effects on Hemodynamics Between Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients With High Shock Index

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 19 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.

Detailed description

In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.

Conditions

• Trauma
• Shock, Traumatic

Interventions

Type	Name	Description
DRUG	Etomidate Injection 0.2 mg/kg	The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg
DRUG	Ketamine injection 2 mg/kg	The induction agent of rapid sequence intubation is ketamine. 2 mg/kg

Timeline

• Start date: 2019-10-01
• Primary completion: 2021-11-30
• Completion: 2021-12-30
• First posted: 2019-10-09
• Last updated: 2022-03-03

Locations

1 site across 1 country: South Korea