NCT04120818

Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

Expression Profile of Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 59 (actual)
• Sponsor: yin ying zhao · Academic / Other
• Sex: All
• Age: 10 Months – 72 Months
• Healthy volunteers: Not accepted

Summary

In this prospective study , a cohort of 58 eyes with congenital cataract from Wenzhou medical university was erolled.33 eyes with congenital cataract was after lensectomy and anterior vitrectomy as post-surger group, 26 eyes without cataract surgery as control group. The cytokines of MCP-1, VEGF, IL-1, IFN-γ, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15 was evaluated

Detailed description

Secondary IOL implantation in aphika children and lensectomy and anterior vitrectomy and primary IOL implantation in children with congenital cataract were both performed by the same surgeon(Z.Y.E) and videos were collected to review the capsular reconstruction condition and lens implantation position. Aqueous humor (100-200 μl) was aspirated from each patient before the surgery. The research was to evaluate the relationship between the cytokine profile in aqueous humor and the state of capsule after Lensectomy and Anterior Vitrectomy.Aqueous humor was obtained , Human Magnetic Luminex Screening Assay was used to determine the aqueous humor levels of cytokines.

Conditions

• Congenital Cataract

Interventions

Type	Name	Description
PROCEDURE	secondary IOL implantation	reopened the fibrotic, closed capsular bag and achieve IOL placement
PROCEDURE	primary IOL implantation	lensectomy and anterior vitrectomy and primary IOL implantation

Timeline

• Start date: 2016-03-04
• Primary completion: 2017-02-12
• Completion: 2017-02-12
• First posted: 2019-10-09
• Last updated: 2019-10-09

Locations

2 sites across 1 country: China