NCT04119596

Study of the Genome, Gut Metagenome and Diet of Patients With Incident Parkinson's Disease

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 138 (actual)
• Sponsor: Atlas Biomed · Industry
• Sex: All
• Age: 45 Years
• Healthy volunteers: Accepted

Summary

A case-control study to identify microbiome and genetic differences between healthy subjects and patients with incident Parkinson's disease.

Detailed description

Two groups of subjects - one including healthy individuals and the other - treatment-naive patients with incident Parkinson's disease - will fill in the food frequency questionnaire, SF-36 questionnaire, HADS questionnaire and the physical activity questionnaire. All subjects must have 0-3 points on Hoehn and Yahr scale and more than 22 points on MoCA scale. DNA microarray genotyping will be used to process the DNA samples of the participants. The data on the composition of the participants' gut microbiota will be obtained through 16S rRNA sequencing of their stool samples.

Conditions

• Parkinson Disease
• Genetic Predisposition

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	16S rRNA gene sequencing	Taking a stool sample for gut microbiome DNA sequencing
GENETIC	DNA-microarray genotyping	Taking a saliva sample for genotyping

Timeline

• Start date: 2020-09-01
• Primary completion: 2022-02-01
• Completion: 2022-02-25
• First posted: 2019-10-08
• Last updated: 2022-07-21

Locations

1 site across 1 country: Russia