NCT04119037

Cordotomy in Reducing Pain in Patients With Advanced Cancer

Percutaneous Cordotomy for Pain Palliation in Advanced Cancer

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial studies how well cordotomy works in reducing pain in patients with cancer that has spread to other places in the body (advanced). Cordotomy is performed on the spinal cord with a needle and guided by computed tomography scans and is designed to help reduce pain. This study is being done to learn if a cordotomy reduces pain in patients with unmanageable cancer pain.

Detailed description

PRIMARY OBJECTIVES: I. Assess the efficacy of cordotomy for patients with unilateral advanced cancer pain. SECONDARY OBJECTIVES: I. Define the patient experience of cordotomy for cancer pain refractory to palliative care. II. Determine whether magnetic resonance imaging (MRI) can be used as a noninvasive biomarker for a successful cordotomy. OUTLINE: Patients are randomized to 1 of 2 groups. GROUP I: Patients undergo a cordotomy over 1-2 hours. GROUP II: Patients receive morphine via injection into the spine and undergo a fake cordotomy over 1-2 hours. After completion of study, patients are followed up at 2 weeks and once every month for up to 6 months.

Conditions

• Advanced Malignant Neoplasm

Interventions

Type	Name	Description
PROCEDURE	Cordotomy	Undergo cordotomy
DRUG	Morphine	Given via injection
OTHER	Questionnaire Administration	Ancillary studies
PROCEDURE	Sham Intervention	Undergo fake cordotomy

Timeline

• Start date: 2019-09-16
• Primary completion: 2028-12-01
• Completion: 2028-12-01
• First posted: 2019-10-08
• Last updated: 2026-03-11

Locations

1 site across 1 country: United States