Trials / Completed
CompletedNCT04117386
Prevalence of HPV-associated Eye Infection and Cytokine Levels in Tears From Patients Diagnosed With Pterygium
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 141 (actual)
- Sponsor
- Chulalongkorn University · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
Prevalence of HPV-associated eye infection and cytokine levels in tears from patients diagnosed with pterygium
Detailed description
The main purpose of this study is to evaluate the prevalence of HPV infection in primary and recurrent pterygium and the association of HPV types collecting from conjunctiva swab and urine. The second purpose is to compare a quantity of cytokines including IL-6, IL-18 and growth factor including VEGF found in tears of patients with primary and recurrent pterygium to participants with free of ocular disease Primary hypothesis \- The prevalence of HPV infection in primary pterygium is difference with prevalence in recurrent pterygium patients. Secondary hypothesis * Ocular HPV infection has association with HPV genitalia infection. * Tears cytokine and growth factor level (IL-6, IL-18 and VEGF) are higher in pterygium HPV infection than non-HPV infection and also more than normal population
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | HPV genotyping assay using HPV GenoArray Diagnostic Kits (Hybribio Ltd., Sheung Wan, Hong Kong) | HPV genotyping assay using HPV GenoArray Diagnostic Kits (Hybribio Ltd., Sheung Wan, Hong Kong) for swab sample collected from pterygium and normal conjunctiva and also for urine collected in Colli-PeeTM device (Novosanis, Belgium) |
| DIAGNOSTIC_TEST | Bio-Plex® 200 system (Bio- Rad, Hercules, CA) | Bioplex was use for measure cytokine IL-6, IL-18 and VEGF from tears collected from Schirmer strip |
Timeline
- Start date
- 2020-01-01
- Primary completion
- 2020-04-30
- Completion
- 2020-06-15
- First posted
- 2019-10-07
- Last updated
- 2020-07-14
Locations
1 site across 1 country: Thailand
Source: ClinicalTrials.gov record NCT04117386. Inclusion in this directory is not an endorsement.