NCT04114747

Renal Physiology During Continuous Renal Replacement Therapy

Impact of Continuous Renal Replacement Therapy on Renal Oxygenation, Blood Flow and Function

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Sahlgrenska University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI. Care is aiming for optimization of circulation and blood flow to the kidneys and avoiding nephrotoxic agents. There is conflicting data concerning whether early or late dialysis is harmful for the kidneys. No one has examined the physiological changes in the kidney when starting dialysis and which blood pressure that leads to most optimal physiological conditions for the kidneys during dialysis. In this descriptive study of 20 ICU patients suffering from AKI we aim to investigate renal physiology when starting continuous renal replacement therapy (CRRT) and also at different target blood pressures using retrograde renal vein thermodilution technique. In parallel we will also investigate and validate this invasive method with contrast enhanced ultrasound of the kidneys.

Conditions

• AKI
• Continuous Renal Replacement Therapy
• Dialysis
• Intensive Care
• Renal Blood Flow
• Renal Failure
• Blood Pressure

Interventions

Type	Name	Description
OTHER	Starting at high or low blood pressure	Using norepinephrine, patients will receive high or low blood pressure to start with and after measurements cross to receive the other blood pressure target

Timeline

• Start date: 2020-11-20
• Primary completion: 2025-08-30
• Completion: 2025-12-31
• First posted: 2019-10-03
• Last updated: 2024-04-18

Locations

1 site across 1 country: Sweden