NCT04108754

Small-vessel Disease Burden and Early Risk of Stroke After Transient Ischemic Attack

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 376 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Predicting the risk of stroke remains a challenge in the management of transient ischemic attack (TIA). In addition to clinical variables, morphological features such as the presence of a diffusion weighted sequence (DWI) lesion and carotid stenosis of at least 50% improve risk stratification and are considered in the literature. score ABCD3-I1. Several studies have shown that brain microhemorrhages are associated with the risk of early stroke in patients with TIA. Data on white matter hypersignals on the T2-weighted sequence or FLAIR (FLuid Attenuated Inversion Recovery) are more conflicting. The global microangiopathic load, including the gaps, the hypersignals of the white matter, the perivascular spaces visible on MRI in the basal ganglia, especially when they are very numerous (\> 20) and the gaps, have recently been described as being associated with stroke risk within 2 to 3 years of TIA or ischemic stroke. To date, the predictive value of global microangiopathic burden on early stroke risk in the course of TIA is not known.

Conditions

• Diagnosis of TIA
• MRI

Interventions

Type	Name	Description
OTHER	microangiopathic burden	to determine the value of the global microangiopathic burden on the prediction of early stroke risk in a homogeneous cohort of TIA.

Timeline

• Start date: 2018-08-01
• Primary completion: 2018-08-01
• Completion: 2018-12-01
• First posted: 2019-09-30
• Last updated: 2019-09-30

Locations

1 site across 1 country: France