Trials / Recruiting
RecruitingNCT04107285
Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy
A Study of Longitudinal Neurocognitive and Neuroimaging Evaluations for Adult Patients With Lymphoma Receiving CD19 CAR T Cell Therapy
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 120 (estimated)
- Sponsor
- Memorial Sloan Kettering Cancer Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to learn about possible changes in cognitive (mental) abilities, such as memory skills and concentration, and in brain anatomy (structure) and function, in people with lymphoma receiving CAR-T therapy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | neurocognitive evaluations | The test battery consists of validated and reliable measures of attention, executive functions and memory. |
| DIAGNOSTIC_TEST | brain MRIs | Patients will undergo baseline and follow-up research MRIs in the same scanner at MSKCC (3 Tesla scanner (GE, Discovery 750W, USA) with a GEM HNU 24-channel head coil) (total scan duration=15 minutes). |
| OTHER | Blood samples | Research blood samples will be collected pre-CAR T infusion; day of CART infusion (day 0), and post-infusion days 7, 14, 21, 28 (+/- 7 days), at start of neurotoxicity, and at 3-4 months and 6-7 months post-CART. |
Timeline
- Start date
- 2019-09-25
- Primary completion
- 2026-09-01
- Completion
- 2026-09-01
- First posted
- 2019-09-27
- Last updated
- 2025-10-24
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04107285. Inclusion in this directory is not an endorsement.