NCT04103788

Evaluation of Increased Absorption of a Curcumin Emulsion (CurQ+) in Healthy Volunteers

Evaluation of Increased Absorption of a Curcumin Emulsion (CurQ+) in Healthy Volunteers Either Following Enzymatic Hydrolysis Pre-Treatment or Direct Analysis of Split Serum Samples

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: ESM Technologies, LLC · Industry
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study is intended to evaluate the comparative effects of direct analysis of serum samples versus pre-treatment with enzymatic hydrolysis in split samples obtained from dosing with a highly absorbed curcumin emulsion product that is commercially available as BIOCURC.

Detailed description

When curcumin is absorbed by the body, it is primarily found in the bloodstream as curcumin glucuronide (C-gluc) and curcumin sulfate (C-SO4) metabolites. Traditionally bioavailability studies have performed an enzymatic hydrolysis pre-treatment of serum samples with both a glucuronidase and a sulfatase enzyme in order to produce free curcumin for analysis via HPLC. In subsequent years, standards have become available for the metabolites (C-gluc \& C-SO4) that make it possible to determine these compound levels directly in serum samples using HPLC-MS-MS. Initial pilot work had indicated that enzymatic hydrolysis was producing falsely elevated results for bioavailability. We wanted to evaluate this in a more formal setting.

Conditions

• Bioavailability

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	95% Curcuminoid Powder	1200 mg curcuminoids
DIETARY_SUPPLEMENT	CurQ+	400 mg curcuminoids + coconut oil + polysorbate

Timeline

• Start date: 2018-03-27
• Primary completion: 2018-04-14
• Completion: 2018-12-13
• First posted: 2019-09-25
• Last updated: 2021-12-13

Locations

1 site across 1 country: United States