NCT04103346

Reducing Particulate Matter-associated Cardiovascular Health Effects for Seniors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

Exposure to fine particulate matter (PM2.5) air pollution is an established risk factor for cardiovascular (CV) morbidity.

Detailed description

This is a randomized double-blind placebo-controlled (sham filtration) crossover trial comparing the effectiveness bedroom-only portable indoor air filtration units \[AFUs\] to reduce personal PM2.5 exposures and improve cardiometabolic health. The health benefits (primary outcome: resting BP) will be evaluated over acute (4-day) and long-term (4-week) periods in 50 nonsmoking elderly adults living in a senior facility impacted by near-roadway pollutants. Because of COVID-19 restrictions that occurred during the trial, certain outcome measures were removed from the protocol, as they could not be performed: 24-hr Blood Pressure, Heart Rate Variability (HRV), BpTRU BP measurements, and WatchPAT. Other outcome measures were not removed from the protocol, but data could not be collected for them because of COVID restrictions.

Conditions

• Cardiometabolic Health

Interventions

Type	Name	Description
OTHER	air filtration with air purifier with hepa filter	long-term (4 week) air filtration with the Holmes HAP8650B-NU-1 air purifier in the residence of low-income seniors impacted by roadway pollutants.
OTHER	sham	air purifier running with air filter removed

Timeline

• Start date: 2020-02-24
• Primary completion: 2024-11-01
• Completion: 2024-11-01
• First posted: 2019-09-25
• Last updated: 2026-01-16
• Results posted: 2026-01-16

Locations

1 site across 1 country: United States