NCT04103242

Abundance of Lactobacillus in Endometrium Affected by Chronic Endometritis

Difference in Relative Abundance of Lactobacillus in Endometrium With and Without Histologically Proven Chronic Endometritis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 23 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Infertile women undergoing hysteroscopy for diagnostic or therapeutic indication are asked to donate a sample of endometrium. Endometrial samples of study participants are examined for signs of chronic endometritis by immunohistochemical analysis. High-throughput sequencing of the microbial 16s ribosomal ribonucleic acid (rRNA) subunit is performed to identify and quantify the microbes present in the sample. Obstetric and reproductive outcome is recorded 12 months after hysteroscopy (telephone interview).

Conditions

• Non Specific Chronic Endometritis
• Infertility, Female

Interventions

Type	Name	Description
OTHER	16s rRNA gene sequencing	High-throughput sequencing of the microbial 16s rRNA subunit to define the abundance of microbial phyla and genera

Timeline

• Start date: 2018-01-02
• Primary completion: 2020-02-12
• Completion: 2021-02-28
• First posted: 2019-09-25
• Last updated: 2024-12-04

Locations

1 site across 1 country: Switzerland