Trials / Unknown
UnknownNCT04101604
Biomarkers of Common Eye Diseases
Using Next-Generation Sequencing Technology to Identify Biomarkers of Common Eye Diseases
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 220 (estimated)
- Sponsor
- Sun Yat-sen University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal vasculopathy. Our study may provide new insight into the underlying mechanisms, and reveal novel predictors and intervention targets for the diagnosis, prognosis and treatment of these diseases.
Detailed description
The pathogenesis of common eye diseases such as uveitis (including Behcet's disease (BD) and Vogt-Koyanagi-Harada disease (VKH)), diabetic retinopathy (DR), age-related macular degeneration (AMD) and polypoid choroidal vasculopathy (PCV) remains unknown. Although immunosuppressants, anti-vascular endothelial growth factor (VEGF) agents, and pars plana vitrectomy (PPV) have been widely used for treatment, the current therapeutic options are limited. In addition, there is a lack of biomarkers to indicate the prognosis and treatment response of these diseases. The aim of this study is to identify biomarkers and to provide a new target for individualized diagnosis and treatment of common eye diseases based on single cell sequencing technology.
Conditions
- Uveitis
- Diabetic Retinopathy
- Age-related Macular Degeneration
- Polypoidal Choroidal Vasculopathy
- VKH Syndrome
- Behçet Disease
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Collection of blood samples | Collection of blood samples for DNA extraction and genetic characterization, and for identification of peripheral blood biomarkers using single-cell transcriptomics and mass cytometry. |
Timeline
- Start date
- 2019-09-26
- Primary completion
- 2020-10-01
- Completion
- 2021-10-01
- First posted
- 2019-09-24
- Last updated
- 2019-09-27
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04101604. Inclusion in this directory is not an endorsement.