NCT04101474

Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this study we will assess the effect of Ketamine infusion on depressive symptoms and in particular its effect on Suicidal behavior, ideation and thoughts in patients with treatment- resistant MDD.

Detailed description

A Twice repetition of IV infusion of 0.5 mg/kg of ketamine produces an antidepressant response in individuals with treatment-resistant MDD The work aims to: 1. To assess the onset of action and degree of improvement and the duration of antidepressant effect of ketamine in a sample of patients with treatment -resistant major depressive disorder. 2. To find out whether the onset of Ketamine antidepressant effect is associated with an improvement of suicidality in those patients.

Conditions

• Treatment Resistant Depression

Interventions

Type	Name	Description
DRUG	Ketamine	Ketamine is a high-affinity, noncompetitive N-methyl-D- aspartate (NMDA) glutamate receptor antagonist it has been used in anesthesiology for more than 50 years the time course of antidepressant response to ketamine is characterized by an initial reduction in depressive symptoms within 2 h

Timeline

• Start date: 2020-09-01
• Primary completion: 2021-10-01
• Completion: 2021-10-01
• First posted: 2019-09-24
• Last updated: 2025-03-05

Locations

1 site across 1 country: Egypt